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Nigel Adkins will be without suspended striker Lee Barnard and midfielder Adam Lallana (knee) for his first game as Southampton boss.Frazer Richardson (shoulder) is still sidelined while Dan Seaborne (foot) and Lee Holmes (groin) are both doubtful.
MK Dons skipper Dean Lewington is available after suspension and Luke Howell could recover from a dead leg.
Striker Aaron Wilbraham is expected to be on the bench as he awaits his first appearance of the season.
MK Dons captain Dean Lewington told BBC Three Counties Radio:"It's just another game for us, Southampton or whoever you play, you don't get any more points for beating them.
"We're looking to put that right, but for me it's not really a big issue that it's Southampton."