Chelsea begin their quest to land an elusive UEFA Champions League crown with a trip to MSK Zilina.
Having returned themselves to the summit of English football last season, the Blues are now more determined than ever to crack the continent.
Success in Europe's premier club competition remains the Holy Grail for all concerned at Stamford Bridge, with owner Roman Abramovich desperate to get his hands on the top prize.
They will hope that the 2010/11 campaign proves to be the one in which their long wait comes to an end, having come agonisingly close in the recent past.
Chelsea will, however, be wary of suffering an early slip-up when they head for Slovakia on Wednesday night.
A tricky trip to Eastern Europe is set to pitch them against group stage debutants Zilina, who will be looking to claim a prized scalp.
The Blues can take heart, though, from the fact that they secured a 5-0 aggregate victory over the Slovaks in the qualifying rounds back in 2003/04.
In fact, their record against Slovakian sides, which stretches to four games, has seen them build up a cumulative score of 9-0.
ChallengeZilina boss Pavel Hapal is well aware of the task facing his side in midweek, but expects them to give a good account of themselves.
He said: "It's a great challenge for me and I'm really looking forward to it. On the other hand, we won't sell ourselves short.
"We want to show our supporters quality football and we'd like to get some points from our meeting with Chelsea.
"We respect our opponents; they're a really big club. Chelsea are obviously superior to us, but football is about 11 players playing against 11 players and we want to walk off with our heads high after the match."
Hapal's endeavours will be aided by the fact that Zilina have a fully-fit squad from which to choose.
MissingChelsea, on the other hand, are set to be without a number of their key men.
Talismanic frontman Didier Drogba is set to start a two-match ban, having been dismissed against Inter Milan in the last 16 last term.
Frank Lampard is also unavailable to Carlo Ancelotti as he nurses his way back to full fitness following a hernia operation.
Jose Bosingwa is edging his way back into contention, but will not be risked, while Ashley Cole is another who has been left behind in London.
The missing men could have handed Ancelotti something of a selection poser, but the Italian, in a Jose Mourinho-esque manner, has already named his starting XI.
He said: "I've already made a decision about the starting lineup: Cech, Ivanovic, Alex, Terry, Zhirkov, John Obi Mikel, Essien, Benayoun, Malouda, Anelka, Sturridge.
"Zilina are a good team. I saw their play-off against Sparta. They deserved to go through. We have to be careful because they are a very organised side, especially in defence, and can cause us problems."